Preparation of biodegradable polymer nanoparticles stabilized with the poly (vinyl alcohol)-sodium dodecyl sulfate mixture: Effect of the lactide/glycolide molar ratio

Abstract

Abstract: This study examines the effects of the lactide/glycolide molar ratio on the synthesis of polymeric nanoparticles using a PVA-SDS stabilizers solution. PLA was obtained with a ratio of 100/0, while PLGA was synthesized at ratios of 88/12 and 64/36. Polymerizations employed ROP at 130°C with stannous oc-tanoate and 1-dodecanol as catalysts. Polymerizations were conducted through ring opening at 130°C with stannous octanoate and 1-dodecanol as catalyst and co-catalyst. Characterized polymers were used to pre-pare emulsions stabilized with polyvinyl alcohol (15 g/L) alone or mixed with sodium dodecyl sulfate of various molecular weights (MW=13-23, 31-50 and 85-124 KDa). These emulsions were stored in phos-phate-buffered saline for 28 days at 37.4°C. Colloidally stable emulsions were achieved using different poly (vinyl alcohol) concentrations, with the lactide/glycolide molar ratio influencing particle diameter. The elec-trostatic stabilizer formed by the poly (vinyl alcohol)-sodium dodecyl sulfate mixture demonstrated .Superior stabilization compared to poly (vinyl alcohol) alone, representing a novel finding. Moreover, the poly (vinyl alcohol-sodium dodecyl sulfate) mixture showed reduced water diffusion into the nanoparticles compared to poly (vinyl alcohol) alone, as evidenced by molecular weight and pH measurements. Addition-ally, the degradation of poly (lactic acid) and poly (lactic-co-glycolic acid) films was investigated; pH measurements in the immersed solutions showed that the degradation was increased with higher glycolide content.