Structural study and antimicrobial evaluation of some transition metal complexes with 3-(2-amino-4-methylphenyl)-2-thioxo-2,3-dihydroquinazolin-4(3H)-one

Abstract

The quinazolin-4-one natural products are of high importance biological activity; thus, they were widely studied for pharmaceutical activities. Because of the previously mentioned in this research is underway to prepare a new derivative of quinazolin to know the coordination of the derivative to a number of transition metal ions. During the preparation of the complexes and then investigate biological activity of the derivative and complexes. The new preparation was ligand blending of paying disproportionate amounts of formaldehyde and amines presence of a compound carbon disulfide in ethanol solution. Use this ligand in the preparing many new complexes with ions of some transition elements (Cu II, Co II, and Ni II). Isolated as well as diagnosed and studied the structures of all solid-state complexes to study the physical properties and analytical technique using absorption flame and technical analysis clucking elements (C.H N. S) in addition to the FTIR spectroscopy and UV - visible and measurements of electrical conductivity and magnetic measurements at room temperature. It has been demonstrated a number of characteristics and behavioral composition shows that ligand wire bidented behavior in all the complexes prepared. Where it has been associated with metallic ion via nitrogen atom related to amino group, also sulfur atom.