Kinetic profile of silver and zinc oxide nanoparticles by intraperitoneal injection in mice , a comparative study

Sarab Mohammed M. Razooki, Adel M. Rabee


To investigate the kinetic profile (Absorption , distribution , and excretion ) of intraperitoneal injected Ag NPs (24.52 nm ) and ZnO NPs (25.16 nm) in Albino mice , a single dose of the two kinds of NPs (100 mg/kg) were used for comparison .Kinetic profile in blood clarified shorter time ( T max ) were spend by ZnO NPs to be absorbed compared with longer one recorded by Ag NPs as their smaller volume of distribution (Vd) to confirm their higher concentration (C max ) with 95 µg/ml compared with Ag NPs which stands on 57.5 µg/ml , also Ag NPs needs longer time of elimination to their half values (t1/2 Elem.) in blood with lower clearance rate (CL) compared with ZnO NPs . This study discussed the distribution profile in different organs over time and pointed a considerable Ag and Zn concentrations specially in liver , spleen , intestine and kidney, also an important levels recorded in lung ,heart , testes and brain. Ag and ZnO NPs excretion manner noted a significant percentage of excretion via feces with 33 % and 83%for Ag NPs and ZnO NPs respectively compared with small percentage recorded with urine .


kinetic , Ag NPs , ZnO NPs , Intraperitoneal , ADME

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Copyright (c) 2019 Sarab Mohammed M. Razooki, Adel M. Rabee

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ISSN: 2303-4521

Digital Object Identifier DOI: 10.21533/pen

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License