Preparation of biodegradable polymer nanoparticles stabilized with the poly (vinyl alcohol)-sodium dodecyl sulfate mixture: Effect of the lactide/glycolide molar ratio

Abstract

Abstract: This study examines the effects of the lactide/glycolide molar ratio on the synthesis of polymeric nanoparticles using a PVA-SDS stabiliser solution. PLA was obtained with a ratio of 100/0, while PLGA was synthesized at ratios of 88/12 and 64/36. Polymerizations employed ROP at 130°C with stannous octanoate and 1-dodecanol as catalysts. Polymerizations were conducted through ring opening at 130°C with stannous octanoate and 1-dodecanol as catalyst and co-catalyst. Characterized polymers were used to prepare emulsions stabilized with polyvinyl alcohol (15 g/L) alone or mixed with sodium dodecyl sulfate of various molecular weights (MW=13-23, 31-50 and 85-124 KDa). These emulsions were stored in phosphate-buffered saline for 28 days at 37.4°C. Colloidally stable emulsions were achieved using different poly (vinyl alcohol) concentrations, with the lactide/glycolide molar ratio influencing particle diameter. The electrostatic stabilizer formed by the poly (vinyl alcohol)-sodium dodecyl sulfate mixture demonstrated .Superior stabilization compared to poly (vinyl alcohol) alone, representing a novel finding. Moreover, the poly (vinyl alcohol-sodium dodecyl sulfate) mixture showed reduced water diffusion into the nanoparticles compared to poly (vinyl alcohol) alone, as evidenced by molecular weight and pH measurements. Additionally, the degradation of poly (lactic acid) and poly (lactic-co-glycolic acid) films was investigated; pH measurements in the immersed solutions showed that the degradation was increased with higher glycolide content.