Preparation, investigation and studying the (physical, spectral and biological activity) of new monomers and heterocyclic compounds containing nitrogen and oxygen

Abstract

This study involves the preparation of seven new compounds, some of them contain two functional groups that are considered condensation monomers. On the other hand, other compounds contain double bonds that are considered addition monomers. They started from 2- amino Thiazole with 2-hydroxy benzaldehyde (salicylaldehyde) in ethanol and hydrochloric acid to prepare azo compound (A), which reacted with acetophenone derivatives (p-bromo, p-chloro and p-hydroxy acetophenone) to prepare chalcone monomers derivatives (H1-H3). Also, the work includes preparing seven-membered heterocyclic rings through two consecutive steps; the first step includes the preparation of Schiff base compound (S). The second step includes the preparation of the oxazepine derivatives (Z1, Z2) through the cyclic closure of compound (S) with the (maleic, phthalic) anhydrides, respectively. All compounds were investigated with FT-IR, H1NMR, and 13CNMR techniques. The physical properties and the antibacterial activity were also studied for all the prepared compounds and showed good results.